I enjoy how no one has really answered this for you... not. This thread got derailed faster than most of the ones on the Nebraska Rivals site do, and that's saying something.
As another poster pointed out, the MAF is a way to measure the air going into the engine. Without a MAF, there is no way to actually measure that. What you CAN do without a MAF is estimate that value VERY closely using various other sensors and correlating with oxygen sensor readings.
So, without MAFs, you're subject to the tune's estimation method. Where this can go wrong is if your conditions differ from those that were used to create that tune. Generic tunes using a MAF usually (ok, I'm making this up but it makes too much sense to not be probably true) have a better/more adaptable method to adjust for your car's ability to take in air. By fine tuning a base calibration of an alpha-n tune, you can get it to run better than any MAF using tune, simply due to its ability to respond MUCH faster and not experience the restriction of the MAF in the airflow.