I have an MY2007 and iPhone4 and have not had any trouble. Did a search on Apple support and this seems to be a known issue with the iPhone and could possible be due to decreased signal while in your car. See the following Apple thread:
Apple - Support - Discussions - Popping/Clicking noise when making ...
and also
Weird Popping/Clicking Noise during Call - MacRumors Forums
Hope this helps.
Apple - Support - Discussions - Popping/Clicking noise when making ...
and also
Weird Popping/Clicking Noise during Call - MacRumors Forums
Hope this helps.