I prefer the highest profile possible... low profile tires ride hard, make tons of noise and stress the hell out of the rims on uneven roads (exempli gratia: potholes)...
the best thing to do (if possible) is go to a shop with several test-fit spacers and wheel/tire combos to find what the best tire for your set-up is. You may have to pay the shop some extra money because the time they spend helping you, but in the long run... you will save in peace of mind and safety.
my brother-in-law owns a tire & wheel shop ... more than half the customers that come in have bent rims and damaged tires from running low profile tires. The tires fatigue quicker, problems arise such as broken belts, bubbles forming, more tire wear from camber because the side wall doesn't deform as much in cornering, etc. Look at any race tire, you will never see a low-profile tire on a car that travels for performance and safety. Low profile tires are strictly for a certain look, and you should be aware of the risks prior to mounting them on your rims.
