I agree with Ghufran that the Gallardo is quite a physical car to drive, even with E-gear which I have also. The car feels quite heavy at town speed and has a hard ride. The engine prefers a certain amount of revs, below which it isn't as happy. You usually have company when you drive - a guy in your blind spot with a camera phone - so this needs concentration.
But when your speed rises, the car takes on a different character, becoming lighter to the touch. The high speed ride is excellent considering the body control that comes with it. The engine gets a chance to get into its stride, and feels very strong - and then you realise that you haven't been over 5000rpm yet. As you pass 6000 rpm the car starts to shriek and lunge forward. The e-gear which is a little clunky at town speeds changes character too -particularly in sport - with incredible-sounding short throttle rips that make your spine tingle every time (and I've done 20,000km). I usually drive with my window down to hear the symphony. You can do this with out getting blown away up to quite high speeds due to the inboard seating position.
With the 4wd, the way the car tackles corners is something else. As you apply power, the car goes from mild understeer to 100% neutral and hunkered down, and then leaps from the corner on to the straight. The car will tour OK, but it is best along a winding road with dips and crests. The ease of the e-gear (and the insane engine note that goes with the gear changes) encourages more gear shifts that you would make in a manual. Many times on a Sunday morning I've turned around and gone back to do it all again. My wife sometimes suspects I've got a mistress as she doesn't buy my excuse for being home later than I said I would, but I'm sure you guys will understand.
Apart from the rather stiff feel to the car around town, the main problem with the Gallardo is that you now exist in a parallel universe to everyone else, gazing into space on a nice day and trying to find an excuse to get out of boring meetings to head for the countryside to attack those favourite roads one more time.
I'm looking forward to my M5 getting here, but as you can see, I'm not suffering too much while I wait.